Fernando Monje

Research interest

The research in our group focuses in the elucidation of the mechanisms that regulate the process of cell division. We are specifically interested in understanding the signaling pathways that orchestrate progression through the cell cycle, as well as the molecular mechanisms by which the main mitotic checkpoints regulate the different cell cycle transitions to ensure the fidelity of this process.

Publications

  • “Dispensability of the SAC depends on the time window required by Aurora B to ensure chromosome biorientation”. Muñoz-Barrera M, Aguilar I, Monje-Casas F. PLoS One (2015). 10(12): e0144972. doi: 10.1371/journal.pone.0144972.

  • “Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability”. Muñoz-Barrera M, Monje-Casas F. Proc Natl Acad Sci USA (2014). 111(38): E3996-E4005. doi:10.1073/pnas.1408017111.

  • “Defective histone supply causes condensin-dependent chromatin alterations, SAC activation and chromosome decatenation impairment” Murillo-Pineda M, Cabello-Lobato MJ, Clemente-Ruiz M, Monje-Casas F, Prado F. Nucleic Acids Research (2014). 42(20):12469-82. doi: 10.1093/nar/gku927.

  • “Inhibition of the Mitotic Exit Network in response to damaged telomeres”. Valerio-Santiago M, de los Santos-Velázquez AI, Monje-Casas F. PLoS Genetics (2013). 9(10): e1003859. doi:10.1371/journal.pgen.1003859.

  • “Impaired manganese metabolism causes mitotic misregulation”. García-Rodríguez N, Díaz de la Loza MD, Andreson B, Monje-Casas F, Rothstein R, Wellinger RE. J Biol Chem (2012). 287 (22): 18717-18729.

  • “Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function”. Valerio-Santiago M, Monje-Casas F. The Journal of Cell Biology (2011). 192 (4): 599-614.

Active Grants

  • “Analysis of spindle-associated asymmetries and their role in the regulation of the cell cycle and the mitotic checkpoints”, Ministry of Economy and Competitiveness (BFU2016-76642-P).

  • “Mechanisms of regulation and coordination of chromosome segregation and mitotic exit”, Spanish National Research Council (CSIC, Ref.: 201620I018).

Group members

  • Fernando Monje-Casas (Principal investigator)
  • Ana María Rincón Romero (Post-doctoral researcher)
  • Javier Manzano López (Post-doctoral researcher)
  • Laura Matellán Fernández (PhD student)
  • Inés García de Oya (PhD student)
  • José Carlos Blanco Mira (Technician)
  • Alejandra Álvarez Llamas (Master student)